Temporal profiles of MMP-9, macrophages, TGF-β1, fibroblasts, collagen, and collagen peptides from days 0 to 30 post-MI at different MMP-9 interventions. The profiles include progressive changes in response to MMP-9 intervention at day 1 (····) and day 7 (red dash), as well as reduced MMP-9 intervention strength at day 7 post-MI (green dot-dash), and no intervention (blue line). The initial conditions were set to F(0) = 20 cells/mm3 and MΦ(0) = 5 cells/mm3, Tβ(0) = 0.21 pg/μL, M9A(0) = 7.1 pg/μL, C(0) = 839.5 μg/μL, CM9(0) = 447.6 μg/μL according to the measurements in normal myocardium.
Jin et al. BMC Systems Biology 2011 5:60 doi:10.1186/1752-0509-5-60