Open Access Highly Accessed Research article

Systems biological approach on neurological disorders: a novel molecular connectivity to aging and psychiatric diseases

Shiek SSJ Ahmed12, Abdul R Ahameethunisa3, Winkins Santosh1*, Srinivasa Chakravarthy2 and Suresh Kumar4

Author Affiliations

1 Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur -603 203, Tamil Nadu, India

2 Computational Neuroscience Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai -600 036, Tamil Nadu, India

3 Department of Bioinformatics, School of Bioengineering, SRM University, Kattankulathur -603 203, Tamil Nadu, India

4 Department of Neurology, SRM Medical College Hospital and Research Centre, Kattankulathur -603 203, Tamil Nadu, India

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BMC Systems Biology 2011, 5:6  doi:10.1186/1752-0509-5-6

Published: 12 January 2011

Additional files

Additional file 1:

MeSH based disease categorization. Classification of manually collected 124 diseases based on the MeSH terms. This file is in PSI-MI level 2.5 format and can be viewed by Cytoscape software.

Format: RTF Size: 33KB Download file

Open Data

Additional file 2:

Curated disease protein network (DPN). Disease protein network of 3632 proteins with 6172 interactions. This file is in PSI-MI level 2.5 format and can be viewed by Cytoscape software.

Format: XML Size: 6.6MB Download file

Open Data

Additional file 3:

Extracted disease-disease network (DDN) using scoring algorithm. List of positively scored disease-disease interactions. This file is in PSI-MI level 2.5 format and can be viewed by Cytoscape software.

Format: XML Size: 3.9MB Download file

Open Data

Additional file 4:

Disease and aging interaction. Positively scored interaction between of disease and aging. This file is in PSI-MI level 2.5 format and can be viewed by Cytoscape software.

Format: XML Size: 212KB Download file

Open Data

Additional file 5:

MeSH validated disease interaction pairs. List of MeSH validated disease interactions. This file is in PSI-MI level 2.5 format and can be viewed by Cytoscape software.

Format: XML Size: 1.8MB Download file

Open Data

Additional file 6:

Common pathway network. Common pathway associated disease pairs. This file is in PSI-MI level 2.5 format and can be viewed by Cytoscape software.

Format: XML Size: 8.9MB Download file

Open Data

Additional file 7:

Gene/protein sets uniquely representing specific disease as biomarkers. Disease specific biomarker proteins. This file is in PSI-MI level 2.5 format and can be viewed by Cytoscape software.

Format: XML Size: 227KB Download file

Open Data