Table 4

Effects of seed domain-disease associations based on leave-one-out cross-validation experiments.

Criteria

Cutoff

Random Control (%)

Linkage Interval (%)

Genome-wide Scan (%)


Precision

90%

28.28 (0.42)

33.45 (1.57)

5.34 (0.33)

80%

27.42 (0.76)

32.06 (1.44)

4.79 (0.47)

70%

27.43 (1.06)

29.59 (0.93)

3.97 (0.74)

60%

25.68 (1.04)

30.11 (1.10)

3.58 (0.58)

50%

25.85 (0.73)

28.47 (0.89)

5.35 (1.22)


Mean Rank Ratio

90%

10.90 (0.78)

8.98 (0.64)

10.16 (0.81)

80%

11.23 (0.84)

9.37 (0.92)

10.38 (1.02)

70%

11.68 (1.21)

10.09 (1.05)

10.61 (0.69)

60%

12.37 (0.97)

9.21 (1.01)

10.76 (0.80)

50%

13.47 (0.55)

9.72 (0.98)

10.95 (0.78)


AUC

90%

89.92 (0.30)

90.83 (0.58)

89.87 (0.61)

80%

89.60 (0.22)

90.26 (0.43)

89.66 (0.29)

70%

89.15 (0.17)

89.40 (0.64)

89.46 (0.48)

60%

88.48 (0.59)

90.01 (0.51)

89.32 (0.34)

50%

87.31 (0.28)

89.89 (0.46)

89.16 (0.75)


The small domain-domain interaction network composed of the PDB part of the DOMINE database and the diffusion kernel are used to obtain the results. Results for random controls are mean (standard deviation) of 10 validation runs.

Zhang et al. BMC Systems Biology 2011 5:55   doi:10.1186/1752-0509-5-55

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