Table 2 

Results of leaveoneout crossvalidation experiments on the large network. 

Random Control (%) 
Linkage Interval (%) 
Genomewide Scan (%) 



R^{2} 
BF 
R^{2} 
BF 
R^{2} 
BF 



Precision 
SG 
14.24 (0.37) 
18.64 (0.66) 
18.54 
21.23 
2.17 
2.35 
DK 
16.80 (0.36) 
22.32 (0.60) 
17.36 
27.56 
2.42 
3.47 

Mean Rank Ratio 
SG 
27.27 (0.07) 
19.59 (0.09) 
21.89 
18.07 
26.53 
18.79 
DK 
26.07 (0.11) 
14.96 (0.07) 
20.21 
14.12 
25.34 
14.11 

AUC 
SG 
73.41 (0.07) 
81.15 (0.09) 
78.57 
81.76 
73.38 
81.09 
DK 
74.61 (0.11) 
85.82 (0.07) 
82.36 
86.68 
74.55 
85.72 



The large network indicates the domaindomain interaction network that is composed of the entire DOMINE database and highconfidence interactions in the InterDom database. R^{2 }denotes the ordinary nonBayesian linear regression approach (using Rsquare as scores for candidate domains). BF denotes the domainRBF approach (using Bayes factors as scores for candidate domains). SG denotes shortest path with Gaussian kernel. DK denotes diffusion kernel. Results for random controls are mean (standard deviation) of 10 validation runs. 

Zhang et al. BMC Systems Biology 2011 5:55 doi:10.1186/17520509555 