Figure 4.

Mean PoP of a number of elements in selected mutants. The gene was turned o after the first million of steps. A: PoP of protoporphyrin-IX when the gene HEM15 is turned o, B: superoxide anion and hydroxyl radical when the gene SOD1 is set to "OFF", C-F: PoP of glutamate, cysteine and glutathion C) when ACO1 is set to "OFF". Cysteine reached zero at steady-state, D: ACO1 is set to "OFF" and a source of glutamate is added, E: HEM1 is set to "OFF", F: HEM1 is set to "OFF" and a source of glutamate is added.

Achcar et al. BMC Systems Biology 2011 5:51   doi:10.1186/1752-0509-5-51
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