Figure 1.

Model validation and clusters of over stacked receptors. A) Dose response for reference size n = 1 (no cluster) and various cluster sizes n ∈ {2, 5, 10, 20}. The curves have the same saturation value (lim c = 1 when l → ∞). The slope at the origin is 1/n and the EC50 n/2. B) Efficient concentration according to the degree of clustering. The line is EC50 = n/2 and the circles are the solution of using Eq. 4. C) Results for normalized receptor binding with κ = 1 and for n ∈ {1, 5, 10, 50} sites by receptor (respectively squares, circles, triangles, diamonds) compared to theoretical dose response according to Eq. 4 (dashed lines) with same n. D) Results of normalized receptor binding for three experiments (circles: κ = 0.1, squares: κ = 1, triangles: κ = 10) compared to theoretical dose responses for respective κ according to Eq. 2 (dashed lines).

Caré and Soula BMC Systems Biology 2011 5:48   doi:10.1186/1752-0509-5-48
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