TRN consistency. (A) Digital CTC (digital control) for the four genetic backgrounds. (B) The effective TRN (including only metabolic genes and their regulators) for the double mutant data (fis/hns). The scheme on the right-hand side explains the classification of consistent (checkmark; green link color) and inconsistent (x; orange link color) links. (C) Consistency of the signs of supercoiling-induced gene expression changes with the transcriptional regulatory network.
Sonnenschein et al. BMC Systems Biology 2011 5:40 doi:10.1186/1752-0509-5-40