Table 1

Differences in characteristics among the four H1299 models.

Circumstances

Model description

WT model

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EGFR-WT model

EGFR overexpression

Increased EGFR initial concentration

EGFR overexpression

Increased EGFR initial concentration

Slow rate for the forward reaction of EGFR phosphorylation (k₃)

L858R model A

Mig6 overexpression

Slow rate for the forward reaction of binding of phosphorylated EGFR to Cbl (k₅)

Slow rate for the forward reaction of binding of phosphorylated EGFR to GAP (k₇)

Slow rate for the forward reaction of binding of phosphorylated EGFR to Shc (k₈)

EGFR overexpression

Increased EGFR initial concentration

L858R model B

Increased ubiquitin-dependent EGFR degradation

Increased Cbl initial concentration

(comparison with WT model)

Naruo et al. BMC Systems Biology 2011 5:29   doi:10.1186/1752-0509-5-29