BMC Systems Biology

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Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity

Yoshimi Naruo1,2, Takeshi Nagashima1, Ryoko Ushikoshi-Nakayama1, Yuko Saeki1, Takashi Nakakuki3, Takashi Naka4, Hiroshi Tanaka2, Shih-Feng Tsai5 and Mariko Okada-Hatakeyama1*

Author Affiliations

1 Laboratory for Cellular Systems Modeling, RIKEN Research Center for Allergy and Immunology (RCAI), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

2 Department of Systems Biology, Bioinformatics, Graduate School of Biomedical Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo 113-8510, Japan

3 Department of Mechanical Systems Engineering, Faculty of Engineering, Kogakuin University, 1-24-2 Nishi-Shinjuku, Shinjuku-ku, Tokyo 163-8677, Japan

4 Department of Information Science, Faculty of Information Science, Kyushu Sangyo University, 2-3-1 Matsukadai, Higashi-ku, Fukuoka 813-8503, Japan

5 Division of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli 350, Taiwan

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BMC Systems Biology 2011, 5:29 doi:10.1186/1752-0509-5-29

Published: 18 February 2011

Additional files

Additional file 1:

Supplementary Information. This PDF file contains all additional figures and tables referenced in the text.

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Additional file 2:

H1299 model. This XML file contains our model represented by SBML.

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