Resolution:
## Figure 2.
Network properties of the correlation network (CN) and Gaussian graphical model (GGM)
inferred from a targeted metabolomics population data set (1020 participants, 151
quantified metabolites). A+B: Graphical depiction of significantly positive edges in both networks, emphasizing
local clustering structures. Each circle color represents a single metabolite class.
C+D: Histograms of pairwise correlation coefficients (i.e. edge weights) for both networks. Green lines
indicate the median values, red lines denote a significance level of 0.01 with Bonferroni
correction. The CN displays a general bias towards positive correlations throughout
all metabolites. For the GGM, the median value lies around zero and we observe a shift
towards significantly positive values. E+F: Modularity between metabolite classes measured as the relative out-degree from each
class (rows) to all other classes (columns). The GGM (right) shows a clear separation
of metabolite classes, with some overlaps for the different phospholipid species diacyl-PCs,
lyso-PCs, acyl-alkyl-PCs and sphingomyelins. Values range from white (0.0 out-degree
towards this class) to black (1.0). PCs = phosphatidylcholines.
Krumsiek |