Email updates

Keep up to date with the latest news and content from BMC Systems Biology and BioMed Central.

Open Access Highly Accessed Research article

Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data

Jan Krumsiek1, Karsten Suhre12, Thomas Illig3, Jerzy Adamski4 and Fabian J Theis15*

Author Affiliations

1 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Germany

2 Faculty of Biology, Ludwig-Maximilians-Universität, Planegg-Martinsried, Germany

3 Institute of Epidemiology, Helmholtz Zentrum München, Germany

4 Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Germany

5 Department of Mathematics, Technische Universität München, Germany

For all author emails, please log on.

BMC Systems Biology 2011, 5:21  doi:10.1186/1752-0509-5-21

Published: 31 January 2011

Additional files

Additional file 1:

Further results on computer-simulated networks.

Format: PDF Size: 419KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Effects of genetic variation on GGM calculation.

Format: PDF Size: 129KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

Modularity: Optimized partitioning and weighted calculation.

Format: PDF Size: 120KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 4:

Stability of the GGM with respect to changes in the underlying data set.

Format: PDF Size: 75KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 5:

comparison with low-order partial correlation approaches.

Format: PDF Size: 153KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 6:

Literature-curated pathway model of human fatty acid biosynthesis and degradation.

Format: XLS Size: 14KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data