Illustration of the Signaling Pathways and Interactions Initiated by TNF-R1. Ligand stimulated TNF-R1 activates two major signaling pathways, pro- and anti-apoptotic cellular responses (red and blue background, respectively). The ligand-receptor interaction and signal complex formation is outlined in the green area.
Schliemann et al. BMC Systems Biology 2011 5:204 doi:10.1186/1752-0509-5-204