Table 1

Initial values for the parameters in the model

Parameter

Untransformed Value (at τ = 21 mins)

Units

Reference


Basal transcription rate kA

75

molecules/min

[70]

RNAP binding <a onClick="popup('http://www.biomedcentral.com/1752-0509/5/201/mathml/M18','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/5/201/mathml/M18">View MathML</a>

12/10000

Dimensionless

[42]

Dna-ATP binding <a onClick="popup('http://www.biomedcentral.com/1752-0509/5/201/mathml/M19','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/5/201/mathml/M19">View MathML</a>

1/10000

Dimensionless

[18], †

RNAP amount P0

5050

molecules

[41]

RIDA rate kR

10

molecules/min

[24]

Replication rate kΛ

1/40

genome equivalents/min

[8]

non-specific binding sites NNS

5 × 106

(genome equivalent)-1

[42]


The parameters are fixed with the values in the table for τ = 21 mins and then are able to vary for the other values of τ in order to fix the ratio of DnaA-ATP:chromosome length at the moment of initiation (t = X). †: Chiara Sag-gioro, Anne Olliver, Bianca Sclavi: Multiple levels of regulation in the growth rate dependence of DnaA expression, submitted.

Grant et al. BMC Systems Biology 2011 5:201   doi:10.1186/1752-0509-5-201

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