Resolution:
## Figure 5.
Comparisons of parameter values between the loss-of-function and interference models
and strengths between the CLV1 and CRN receptor pathways. A) Parameter sets for the two models and the background distribution presented with
the help of a PCA-analysis. The parameter sets are projected on the two largest principal
components (E_{1 }and E_{2}). B-E) Distributions of parameter values of parameters highlighted in the analysis
step. B-C) Comparing parameter value distributions of parameters k_{3 }(B) and t_{1 }(C) for the loss-of-signal model (black) and the background distribution (gray). D-E)
Comparing parameter value distributions of parameters s_{1 }(D) and s_{2 }(E) for the interference model (white) and the background distribution (gray). Axes
have log-scale and have ranges [0.23, 12] (B), [0.082, 9.9] (C), [0.24, 9.5] (D),
and [0.21, 7.6] (E). Corresponding ROC-curves are presented in each plot with axes
ranging from 0 to 1.0. F-H) The parameters k_{3 }and k_{6 }set the strengths of the signals from bound CLV1 and CRN receptors. To compare the
strengths of the two receptor pathways we plot each parameter multiplied with respective
concentration of bound receptors. The comparison is done for the loss-of-signal model
(F), the interference model (G), and the background distribution (H). Number of parameter
sets for which the CRN pathway is stronger than the CLV1 pathway: Loss-of-signal -
0 (0%), Interference - 17 (3.2%), Background - 1696 (6.9%).
Sahlin |