Table 1

Receptor densities

Measured parameters

Model parameters

Value

Unit

Value

Unit


VEGFR1

Luminal EC (normal)

550

rec/EC

1.21 × 10-1

pmol/cm3 tissue

Abluminal EC (normal)

550

rec/EC

9.86 × 10-3

pmol/cm3 tissue

Luminal EC (diseased)

3,750

rec/EC

4.38 × 10-4

pmol/cm3 tissue

Abluminal EC (diseased)

3,750

rec/EC

6.54 × 10-2

pmol/cm3 tissue

Myocytes

0

rec/myocyte

0

pmol/cm3 tissue

Tumor cells

1,100

rec/tumor cell

2.81 × 10-1

pmol/cm3 tissue


VEGFR2

Luminal EC (normal)

350

rec/EC

7.70 × 10-2

pmol/cm3 tissue

Abluminal EC (normal)

350

rec/EC

6.28 × 10-3

pmol/cm3 tissue

Luminal EC (diseased)

300

rec/EC

3.51 × 10-5

pmol/cm3 tissue

Abluminal EC (diseased)

300

rec/EC

5.23 × 10-3

pmol/cm3 tissue

Myocytes

0

rec/myocyte

0

pmol/cm3 tissue

Tumor cells

550

rec/tumor cell

1.41 × 10-1

pmol/cm3 tissue


NRP1

Luminal EC (normal)

17,500

rec/EC

3.74

pmol/cm3 tissue

Abluminal EC (normal)

17,500

rec/EC

3.05 × 10-1

pmol/cm3 tissue

Luminal EC (diseased)

20,000

rec/EC

2.34 × 10-3

pmol/cm3 tissue

Abluminal EC (diseased)

20,000

rec/EC

3.49 × 10-1

pmol/cm3 tissue

Myocytes

34,500

rec/myocyte

2.06

pmol/cm3 tissue

Tumor cells

39,500

rec/tumor cell

1.01 × 101

pmol/cm3 tissue


NRP2

Luminal EC (normal)

0

rec/EC

0

pmol/cm3 tissue

Abluminal EC (normal)

0

rec/EC

0

pmol/cm3 tissue

Luminal EC (diseased)

0

rec/EC

0

pmol/cm3 tissue

Abluminal EC (diseased)

0

rec/EC

0

pmol/cm3 tissue

Myocytes

0

rec/myocyte

0

pmol/cm3 tissue

Tumor cells

39,500

rec/tumor cell

1.02 × 101

pmol/cm3 tissue


EC = endothelial cell; rec = receptors

Extrapolated from receptor density on normal ECs, accounting for different cell surface areas

No NRP2 quantification available; assumed to be the same as NRP1 on tumor cells

Conversions of receptor densities to tissue concentrations:

Abluminal EC receptors (normal): 1.79 × 10-5 (pmol/cm3 tissue)/(rec/EC);

Luminal EC receptors (normal): 2.20 × 10-4 (pmol/cm3 tissue)/(rec/EC);

Abluminal EC receptors (diseased): 1.74 × 10-5 (pmol/cm3 tissue)/(rec/EC);

Luminal EC receptors (diseased): 1.17 × 10-7 (pmol/cm3 tissue)/(rec/EC);

Myocyte receptors: 5.96 × 10-5 (pmol/cm3 tissue)/(rec/myocyte);

Tumor receptors: 2.55 × 10-4 (pmol/cm3 tissue)/(rec/tumor cell);

Myocyte receptor densities are expressed per myonuclear domain

Finley et al. BMC Systems Biology 2011 5:193   doi:10.1186/1752-0509-5-193

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