Additional file 7.
The concentration of free anti-VEGF in the body following anti-VEGF treatment is predicted as properties of the anti-VEGF are varied. A, Effect of microvascular permeability to anti-VEGF between the normal tissue and blood. B, Effect of microvascular permeability to anti-VEGF between the tumor and blood. C, Effect of clearance rate of anti-VEGF. D, Effect of anti-VEGF binding affinity to VEGF. From top to bottom: normal tissue, blood, and tumor. Bold in the legend indicates parameter value used in the current model.
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Finley et al. BMC Systems Biology 2011 5:193 doi:10.1186/1752-0509-5-193