Effect of tumor microenvironment on the response to the anti-VEGF treatment. The fold-change in free VEGF concentration following anti-VEGF treatment is predicted as a function of properties of the tumor microenvironment. A, Effect of neuropilin internalization. B, Effect of VEGF isoform-specific secretion.
Finley et al. BMC Systems Biology 2011 5:193 doi:10.1186/1752-0509-5-193