Table 2

Numerical fitting results of the four models for in vitro experimental data for the EGFP protein and mRNA.

Experiment on EGFP mRNA levels


Fit Err.

Pred. Err.

Parameters


Model 1

1.00

0.98

k1 = 1.38 × 10-4(pmol min)-1,

Model 2

0.13

0.12

k2 = 5.00 × 10-3(pmolh2 min)-1,

h2 = 0.126,

Model 3

1

1

k3h3 = 1.40 × 10-4(pmol min)-1,

c3/km = 1.33 × 103a.u.,

Model 4

0.04

0.05

θ4 = 0.105 pmol,

d4 = 8.1 × 10-3min-1,

h4 = 4.47


Experiment on EGFP protein levels


Fit Err.

Pred. Err.

Parameters


Model 1

0.97

0.81

k1 = 9.90 × 10-5(pmol min)-1,

Model 2

0.46

0.39

k2 = 1.10 × 10-3(pmolh2 min)-1,

h2 = 0.456,

Model 3

1

1

k3h3 = 1.20 × 10-4(pmol min)-1,

c3/km = 1.33 × 103a.u.,

Model 4

0.21

0.12

θ4 = 12.9 pmol,

d4 = 8.6 × 10-3min-1,

h4 = 4.49


The relative value of the error (Fit Error) and the relative value of the prediction error (Pred. Err.) for each model are given, together with the corresponding optimized values of its parameters. The unit of measurements are reported for the dimensional parameters. (a.u. stands for arbitrary units of concentration).

Cuccato et al. BMC Systems Biology 2011 5:19   doi:10.1186/1752-0509-5-19

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