Table 1

The different models RNA interference models for the RNAi-induced mRNA degradation rate δ (Xs, Xm) and their corresponding parameters.

Model 1


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k1: Rate of mRNA-siRNA* complex formation


Model 2


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k2: Rate of mRNA-siRNA* complex formation

h2: Number of siRNA target sites


Model 3


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k3: Rate of mRNA-siRNA* complex formation

c3: Cleavage and dissociation rate of mRNA-siRNA*

h3: Number of siRNA target sites


Model 4


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d4: Maximal degradation rate of the mRNA due to RNAi

θ4: Michaelis-Menten like constant

h4: Number of siRNA target sites



Cuccato et al. BMC Systems Biology 2011 5:19   doi:10.1186/1752-0509-5-19

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