Comparison of the dynamics of the Repressilator models using the original ODEs (55), the GMA approximation, and the moment approach based on the GMA approximation. The mean of the moment approach based on the GMA approximation fits the original ODEs (55) very well up to about t = 400 s. Black bold line: solution of the original ODEs (55); black dashed line: the GMA approximation; Red line: mean of the moment approach based on the GMA approximation; red dashed lines framing around the red line: mean ± standard deviation, which were produced with the moment approach. x-axis is time in second, y-axis is the number of x1 molecules (unitless).
Wu et al. BMC Systems Biology 2011 5:187 doi:10.1186/1752-0509-5-187