Figure 3.

Loop structure regulatory network motif. Three-element regulatory loop-structure motif, which features one miRNA and two proteins. In this structure, one of the proteins would act as a TF by regulating the miRNA, which in turn would target the other protein. The latter would either simply interact with the TF or serve as a TcoF for the regulation of the miRNA. This protein would also be associated with OC according to DDOC.

Schmeier et al. BMC Systems Biology 2011 5:183   doi:10.1186/1752-0509-5-183
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