Heatmap of a sub-network for significant TF BRCA1. BRCA1 can be regarded as the most significant node for OC relevant miRNA regulation. It is ranked 1st in both networks NW1000 and NW5000. This TF regulates 50 miRNAs in NW1000, which target 66 proteins involved in OC. The vertically arranged miRNAs are all miRNAs that are predicted to be regulated by BRCA1. The horizontally arranged genes are those that are targeted by the miRNA. BRCA1 is itself targeted by hsa-mir-24-2.
Schmeier et al. BMC Systems Biology 2011 5:183 doi:10.1186/1752-0509-5-183