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Open Access Research article

Robust Control of PEP Formation Rate in the Carbon Fixation Pathway of C4 Plants by a Bi-functional Enzyme

Yuval Hart1, Avraham E Mayo1, Ron Milo2 and Uri Alon1*

Author Affiliations

1 Dept. of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel

2 Dept. of Plant Sciences, Weizmann Institute of Science, Rehovot, Israel

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BMC Systems Biology 2011, 5:171  doi:10.1186/1752-0509-5-171

Published: 24 October 2011

Additional files

Additional file 1:

Model equations for the PPDK system. In this file we elaborate on the PPDK model's equations and their derivation.

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Additional file 2:

Robust Control in the Carbon Fixation Pathway of C4 Plants - Supplementary Information. In this file we present further analysis of the model's stability and the effects of perturbations on robustness. We elaborate on the estimation of PEP formation rate and PPi sources in the chloroplast. We show the dependency of the ratio between ternary to binary complexes on avidity and modification rate and finally discuss a possible implication of the model to the metabolic pathway in bacteria.

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