Drug targets GO terms variation along pathways. Integration of GO biological process (BP) analysis and pathway positions. Proteins at the source (0-0.2), center (0.4-0.6) and end (0.8-1) of pathways in C.Prot and drug targets restricted to C.Prot are submitted to GO analysis. All the BP terms with P-values < 0.1% in at least one case are reported and we see that the general strong reduction for central pathway position (Figure 1D) is rather uniform over the BPs. The barplots represent the coverage of the GO terms.
Burkard et al. BMC Systems Biology 2011 5:17 doi:10.1186/1752-0509-5-17