Network and pathways statistics. (A) Node degree (number of edges). Note the strong shift of C.Prot towards higher values. We also observe the absence of shift of the tissue specific genes (Spe.Trans) and the gradual shift from low abundant C.Prot entities to high abundant ones. (B) Eigenvector centrality values also display similar shifts, although in this case Spe.Trans even reverses the trend and differences between low and high abundant C.Prot are more modest. (C) Relative positions in pathways; 0 = beginning, 1 = end. No real bias for C.Prot but a strong preference for central position for its abundant proteins. Spe.Trans and low abundant C.Prot are more spread over all possible positions. (D) The same for drug targets. Note the strong shift towards initial positions for C.Prot drug targets, which significantly amplifies the already present preference of drug targets for such positions.
Burkard et al. BMC Systems Biology 2011 5:17 doi:10.1186/1752-0509-5-17