Table 2

Correlation between membrane interaction content and centrality-lethality rule for different PPI techniques.

Technique

Unique interactions

Fraction of membrane interactions

Kendall's tau

Kendall's tau (p-value)

Indess (5)

Assortativity coefficient


Affinity Capture-MS

26350

0.14

0.277

9.46E-96

1.864

-0.071


Co-localization

351

0.18

0.181

4.14E-04

1.996

0.214


Co-purification

1217

0.28

0.127

1.07E-04

1.558

-0.227


Reconstituted Complex

1959

0.29

0.167

3.49E-11

2.069

-0.101


Two-hybrid (without Miller et al (2005))

7040

0.29

0.141

9.11E-20

1.657

-0.107


Affinity Capture-Western

4953

0.30

0.188

3.92E-24

1.894

0.112


BIOGRID (all techniques)

94877

0.30

0.190

4.98E-70

1.312

-0.102


Affinity Capture-RNA

1187

0.31

0.119

5.07E-05

1.833

-0.857


Biochemical Activity

5355

0.31

-0.034

0.104

0.792

-0.460


Co-fractionation

574

0.58

0.044

0.274

0.833

-0.163


PF-PCA

2395

0.65

0.018

0.505

0.904

0.171


SU-2HY

1941

0.99

-0.004

0.928

1.187

-0.074


Note: the table was sorted in ascending order according the column with the "fraction of membrane interactions".

The Kendall's tau and Indess(5) are both inversely correlated to the content of membrane interactions, while the assortativity coefficient is not.

Brito and Andrews BMC Systems Biology 2011 5:169   doi:10.1186/1752-0509-5-169

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