Table 1

Analysis of cell compartment enrichment in the BIOGRID database.

GO ID

GO Term

Median p-value


Overrepresented categories:


32991

macromolecular complex

4.96E-105


43234

protein complex

1.80E-78


44428

nuclear part

1.06E-66


5622

intracellular

2.74E-54


44424

intracellular part

3.72E-53


44422

organelle part

8.61E-51


44446

intracellular organelle part

8.61E-51


5634

nucleus

2.43E-52


43229

intracellular organelle

8.85E-48


43226

organelle

8.85E-48


31981

nuclear lumen

1.27E-53


44451

nucleoplasm part

5.98E-38


5654

nucleoplasm

1.75E-38


44464

cell part

3.54E-33


5623

cell

4.46E-33


43228

non-membrane-bounded organelle

1.67E-34


43232

intracellular non-membrane-bounded organelle

1.67E-34


43233

organelle lumen

1.02E-31


31974

membrane-enclosed lumen

1.02E-31


43231

intracellular membrane-bounded organelle

4.99E-31


43227

membrane-bounded organelle

4.99E-31


16591

DNA-directed RNA polymerase II, holoenzyme

4.98E-11


5694

chromosome

7.67E-15


30529

ribonucleoprotein complex

2.76E-12


5730

nucleolus

6.52E-13


502

proteasome complex

2.37E-06


44427

chromosomal part

1.61E-14


5856

cytoskeleton

3.25E-07


5679

chromatin remodeling complex

1.70E-09


123

histone acetyltransferase complex

5.87E-10


44430

cytoskeletal part

1.65E-05


22624

proteasome accessory complex

9.47E-04


5838

proteasome regulatory particle

9.47E-04


44452

nucleolar part

2.30E-08


5669

transcription factor TFIID complex

7.26E-03


5681

spliceosome

4.85E-04


119

mediator complex

3.91E-04


124

SAGA complex

1.04E-05


5667

transcription factor complex

3.06E-04


812

SWR1 complex

1.15E-03


44453

nuclear membrane part

6.00E-03


Underrepresented categories:


943

retrotransposon nucleocapsid

2.88E-05


31224

intrinsic to membrane

1.22E-05


44429

mitochondrial part

3.18E-04


5740

mitochondrial envelope

4.89E-03


16021

integral to membrane

7.67E-05


44425

membrane part

1.85E-03


5743

mitochondrial inner membrane

7.18E-03


5739

mitochondrion

6.34E-03


The median p-values were calculated after sampling 10 random sets of 1000 interactions from BIOGRID. P-values are shown after Bonferroni's correction for multiple hypotheses.

Brito and Andrews BMC Systems Biology 2011 5:169   doi:10.1186/1752-0509-5-169

Open Data