Table 1 |
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Analysis of cell compartment enrichment in the BIOGRID database. |
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|
GO ID |
GO Term |
Median p-value |
|
|
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|
Overrepresented categories: |
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|
|
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|
32991 |
macromolecular complex |
4.96E-105 |
|
|
||
|
43234 |
protein complex |
1.80E-78 |
|
|
||
|
44428 |
nuclear part |
1.06E-66 |
|
|
||
|
5622 |
intracellular |
2.74E-54 |
|
|
||
|
44424 |
intracellular part |
3.72E-53 |
|
|
||
|
44422 |
organelle part |
8.61E-51 |
|
|
||
|
44446 |
intracellular organelle part |
8.61E-51 |
|
|
||
|
5634 |
nucleus |
2.43E-52 |
|
|
||
|
43229 |
intracellular organelle |
8.85E-48 |
|
|
||
|
43226 |
organelle |
8.85E-48 |
|
|
||
|
31981 |
nuclear lumen |
1.27E-53 |
|
|
||
|
44451 |
nucleoplasm part |
5.98E-38 |
|
|
||
|
5654 |
nucleoplasm |
1.75E-38 |
|
|
||
|
44464 |
cell part |
3.54E-33 |
|
|
||
|
5623 |
cell |
4.46E-33 |
|
|
||
|
43228 |
non-membrane-bounded organelle |
1.67E-34 |
|
|
||
|
43232 |
intracellular non-membrane-bounded organelle |
1.67E-34 |
|
|
||
|
43233 |
organelle lumen |
1.02E-31 |
|
|
||
|
31974 |
membrane-enclosed lumen |
1.02E-31 |
|
|
||
|
43231 |
intracellular membrane-bounded organelle |
4.99E-31 |
|
|
||
|
43227 |
membrane-bounded organelle |
4.99E-31 |
|
|
||
|
16591 |
DNA-directed RNA polymerase II, holoenzyme |
4.98E-11 |
|
|
||
|
5694 |
chromosome |
7.67E-15 |
|
|
||
|
30529 |
ribonucleoprotein complex |
2.76E-12 |
|
|
||
|
5730 |
nucleolus |
6.52E-13 |
|
|
||
|
502 |
proteasome complex |
2.37E-06 |
|
|
||
|
44427 |
chromosomal part |
1.61E-14 |
|
|
||
|
5856 |
cytoskeleton |
3.25E-07 |
|
|
||
|
5679 |
chromatin remodeling complex |
1.70E-09 |
|
|
||
|
123 |
histone acetyltransferase complex |
5.87E-10 |
|
|
||
|
44430 |
cytoskeletal part |
1.65E-05 |
|
|
||
|
22624 |
proteasome accessory complex |
9.47E-04 |
|
|
||
|
5838 |
proteasome regulatory particle |
9.47E-04 |
|
|
||
|
44452 |
nucleolar part |
2.30E-08 |
|
|
||
|
5669 |
transcription factor TFIID complex |
7.26E-03 |
|
|
||
|
5681 |
spliceosome |
4.85E-04 |
|
|
||
|
119 |
mediator complex |
3.91E-04 |
|
|
||
|
124 |
SAGA complex |
1.04E-05 |
|
|
||
|
5667 |
transcription factor complex |
3.06E-04 |
|
|
||
|
812 |
SWR1 complex |
1.15E-03 |
|
|
||
|
44453 |
nuclear membrane part |
6.00E-03 |
|
|
||
|
Underrepresented categories: |
||
|
|
||
|
943 |
retrotransposon nucleocapsid |
2.88E-05 |
|
|
||
|
31224 |
intrinsic to membrane |
1.22E-05 |
|
|
||
|
44429 |
mitochondrial part |
3.18E-04 |
|
|
||
|
5740 |
mitochondrial envelope |
4.89E-03 |
|
|
||
|
16021 |
integral to membrane |
7.67E-05 |
|
|
||
|
44425 |
membrane part |
1.85E-03 |
|
|
||
|
5743 |
mitochondrial inner membrane |
7.18E-03 |
|
|
||
|
5739 |
mitochondrion |
6.34E-03 |
|
|
||
|
The median p-values were calculated after sampling 10 random sets of 1000 interactions from BIOGRID. P-values are shown after Bonferroni's correction for multiple hypotheses. |
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|
Brito and Andrews BMC Systems Biology 2011 5:169 doi:10.1186/1752-0509-5-169 |
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