Membrane associated gene interaction data does not support the centrality-lethality rule. A) The Indess (5), an ad hoc indicator of the centrality-lethality rule, is negatively correlated with the content of membrane interactions (Spearman correlation = -0.72, p = 0.012). Each data point represents a different PPI technique. B) The correlation between Kendall's tau, another ad hoc indicator of the centrality-lethality rule, and the content of membrane interactions using different techniques to generate interaction data (Spearman correlation = -0.83, p = 0.003). 1) Affinity capture - MS, 2) Colocalization, 3) Reconstituted complex, 4) Affinity capture - Western, 5) Affintiy capture - RNA, 6) Two hybrid, 7) Copurification, 8) Bioactivity, 9) Cofractionation, 10) PF-PCA, 11) SU-2HY.
Brito and Andrews BMC Systems Biology 2011 5:169 doi:10.1186/1752-0509-5-169