Table 2

Cell-line specific parameter sets for computational modeling

Initial condition/rate constant

Jurkat

pLKO

Grx1 shRNA

Trx1 shRNA

G6PD shRNA


Grx1-SH (μM)

1.2

1.2

0.62

1.2

1.2


Trx1ox + Trx1red (μM)

0.505

0.505

0.505

0.144

0.505


G6PD (M⋅s-1)

3.75e-4

3.75e-4

2.55e-4

3.75e-4

1.24e-4


Prx2-SH2 (μM)

19.2

19.2

12.5

17.1

16.7


Srx1 (s-1)

3e-3

3e-3

1.74e-3

1.95e-3

3e-3


CAT (μM)

0.9

1.17

0.8

0.9

0.9


Numbers in bold represent altered parameters from the wild-type Jurkat cell line.

Kippner et al. BMC Systems Biology 2011 5:164   doi:10.1186/1752-0509-5-164

Open Data