Variability of non-target redox enzymes. (A) Changes in off-target expression levels for wild-type Jurkat cells relative to pLKO empty vector control cells. Genes with significantly altered mRNA levels are colored green. (B) Changes in off-target expression levels for Grx1 shRNA (blue, circles), Trx1 shRNA (red, diamonds) and G6PD shRNA (orange, triangles), relative to pLKO control. (C) Venn diagram of significant gene changes. Statistical significance for all plots based upon p < 0.05.
Kippner et al. BMC Systems Biology 2011 5:164 doi:10.1186/1752-0509-5-164