Table 1

List of top 13 transcription factors

TF

Periodicity

Phase

Amplitude

Function


ACE2

0.520

45°

0.048

Cell cycle (early G1 specific transcription).

ADR1

0.518

48°

0.047

Glucose repression.

ARO80

0.544

44°

0.066

Aromatic AA degradation

BAS1

0.562

293°

0.082

Recombination. Purine and histidine synthesis.

GAL3

0.452

215°

0.036

Galactose metabolism.

GCN4

0.548

0.085

Main regulator of general AA control.

HAP1

0.449

80°

0.049

Respiration. Heme-responsive. Growth potential.

HAP3

0.503

255°

0.048

Respiration. Subunit of heme-activ'd Hap2/3/4/5.

HAP4

0.620

227°

0.124

Respiration. Subunit of heme-activ'd Hap2/3/4/5.

MSN4

0.595

0.062

Cell cycle. Stress-responsive gene expression.

RLR1

0.515

42°

0.063

Recombination. Transcriptional elongation.

SPT2

0.497

302°

0.108

Cell cycle (interacts w/histones, SWI-SNF).

SWI6

0.631

225°

0.058

Cell cycle (progression from G1 to S phase).


Shown are the transcription factors that remain after iterative filtering for the highest periodicity scores of their α-coefficients. Phase and amplitude were calculated from the best-fit sine waves.

Rao and Pellegrini BMC Systems Biology 2011 5:160   doi:10.1186/1752-0509-5-160

Open Data