Network of transcription factors regulating the yeast metabolic cycle. The time-translation matrix is illustrated as a dynamical model of the α-coefficients of the 13 most significant transcription factors, in which the matrix entries of highest absolute values represent couplings between transcription factors. A line from factor A to factor B indicates that the activity of A affects the activity of B at the next time point. The displayed order of factors minimizes the number of upward arcs (these arcs being grouped on the right side of the figure). This representation can be seen in . Levels of dissolved oxygen in the yeast culture were normalized and included in the dynamical model.
Rao and Pellegrini BMC Systems Biology 2011 5:160 doi:10.1186/1752-0509-5-160