Table 1

Enriched GO terms among the toxicity-modulating genes

GO IDDescription

P-value

Adjusted P-value

x/X* (%)

n/N** (%)


6974

response to DNA damage stimulus

6.8E-19

2.1E-16

15.3

4.8

6259

DNA metabolic process

3.0E-16

4.7E-14

19.0

7.6

6281

DNA repair

2.9E-16

4.7E-14

12.8

3.9

22402

cell cycle process

6.6E-12

5.4E-10

17.4

7.9

6394

RNA processing

2.5E-09

1.5E-07

16.0

7.9

7001

chromosome organization and biogenesis

4.4E-09

2.4E-07

14.4

6.8

6365

rRNA processing

1.3E-08

6.4E-07

9.2

3.5

6260

DNA replication

1.4E-08

6.5E-07

7.8

2.7

278

mitotic cell cycle

2.2E-08

9.3E-07

11.4

5.1

6351

transcription, DNA-dependent

2.4E-08

9.8E-07

11.2

4.9

6302

double-strand break repair

2.5E-08

9.8E-07

4.3

1.0

34470

ncRNA processing

3.4E-08

1.3E-06

11.2

5.0

65004

protein-DNA complex assembly

1.1E-07

3.7E-06

5.9

1.9

723

telomere maintenance

2.0E-05

3.7E-04

3.4

1.0

6395

RNA splicing

2.4E-05

4.4E-04

5.7

2.4

7059

chromosome segregation

4.0E-04

5.0E-03

5.3

2.5

51656

establishment of organelle localization

3.9E-03

3.4E-02

2.5

1.0

7127

meiosis I

4.4E-03

3.8E-02

3.0

1.3


* number of toxicity-modulating genes with GO term/number of toxicity-modulating genes × 100

** number of genes with GO term/number of genes × 100

Table only shows non-redundant GO terms containing between 50 and 500 genes, with FDR adjusted p-value <0.05 and an enrichment of at least 2. For complete table, see supplemental table S3 (Additional file 1).

Svensson et al. BMC Systems Biology 2011 5:157   doi:10.1186/1752-0509-5-157

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