Yeast protein-protein interaction networks. A) Network of proteins whose absence or reduced levels render cells sensitive to MMS B) Sub-network of these proteins involved in RNA processing. Non-essential proteins are in red, essential proteins in green. The size (inverse to the GI50-value) reflects the sensitivity to MMS of the corresponding yeast strains. Classification of severe, intermediate and slight sensitivity was established according to GI50 values (GI50<0.003%, GI50<0.006% and GI50<0.008%, respectively).
Svensson et al. BMC Systems Biology 2011 5:157 doi:10.1186/1752-0509-5-157