Additional file 5.

The pathway distribution of blocked reactions and their SMILEY S1 solutions categories. The figure shows the SMILEY S1 solution category as a percentage of the total number of blocked reactions found within a particular metabolic pathway. The number of blocked reactions within each metabolic pathway and their SMILEY solution type is also shown. Some blocked reactions, such as those involved in amino acid metabolism, are easily bypassed using functionalities already described in the KEGG, represented by category I and II SMILEY solutions. Others, such as those involved in glycan biosynthesis, can only be solved by transport of their causative dead-end metabolite out of the system.

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Rolfsson et al. BMC Systems Biology 2011 5:155   doi:10.1186/1752-0509-5-155