Additional file 2.

Dead-end metabolites can cause multiple blocked reactions. In the majority of cases, dead-end metabolites only cause one blocked reaction. When a dead-end metabolite is at the end or beginning of a reaction cascade however, it inhibits flux through all reactions, which are part of the reaction cascade. The figure shows the number of blocked reactions found in the reaction cascades. For example, there is one reaction cascade, which has 14 blocked reactions.

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Rolfsson et al. BMC Systems Biology 2011 5:155   doi:10.1186/1752-0509-5-155