Open Access Highly Accessed Research article

How neurons migrate: a dynamic in-silico model of neuronal migration in the developing cortex

Yaki Setty12*, Chih-Chun Chen3, Maria Secrier4, Nikita Skoblov5, Dimitrios Kalamatianos6 and Stephen Emmott1

Author Affiliations

1 Computational Science Laboratory, Microsoft Research, Cambridge, CB3 0FB, UK

2 Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel

3 Centre National de la Recherche Scientifique, Paris, France

4 European Molecular Biology Laboratory, Heidelberg, Germany

5 The Faculty of Computational Mathematics and Cybernetics, Moscow State University, Moscow, Russia

6 The Hamilton Institute, National University of Ireland, Maynooth, Ireland

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BMC Systems Biology 2011, 5:154  doi:10.1186/1752-0509-5-154

Published: 30 September 2011

Additional files

Additional file 1:

Recorded simulation of neuronal migration under normal conditions.

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Additional file 2:

Recorded simulation of neuronal migration under reduced Lis1 activity.

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Additional file 3:

Oscillatory association-dissociation behavior of four representative neurons. Neurons are labeled green when they are disassociated from the glial fiber and change their color to red upon association.

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Additional file 4:

Recorded simulation of neuronal migration under reduced DCX activity.

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Additional file 5:

A compressed file of the source code of the model. Written in Java and compiled using Mason (see Material and Methods).

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Additional file 6:

Supplementary information: a control experiments and the design of the reduced activity in-silico experiments.

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