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Open Access Highly Accessed Research article

Identifying Tmem59 related gene regulatory network of mouse neural stem cell from a compendium of expression profiles

Luwen Zhang1, Xiangchun Ju2, Yumin Cheng3, Xiuyun Guo1 and Tieqiao Wen2*

Author Affiliations

1 Department of Mathematics, College of Science, Shanghai University, 99 Shangda Road, Shanghai 200433, China

2 Laboratory of Molecular Neurobiology, Institute of Systems Biology, School of Life Sciences, Shanghai University, 99 Shangda Road, Shanghai 200433, China

3 Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, 149 Yanchang Road, Shanghai 200072, China

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BMC Systems Biology 2011, 5:152  doi:10.1186/1752-0509-5-152

Published: 29 September 2011

Additional files

Additional file 1:

Table S1 for 80 selected genes lists from the tmem59 knock-out microarray experiment included in the analysis. From the tmem59 knock out microarray datasets, 627 genes that differentially expressed with more than 2-fold change were selected as our source of data. In order to focus on much significantly expressed genes related to tmem59, we selected 80 genes for further analysis based on the Differential Ratio following tmem59 knock out. The symbol, Gene ID and function of each gene can be searched in Genbank.

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Additional file 2:

Table S2 for 21 platforms related to 146 microarray datasets about mouse NSCs. Microarrays about NSCs, neurogenesis, glias and central nervous system (CNS) are selected, due to that NSCs are the principal source of constitutive neurogenesis and glias in the CNS. 146 microarray datasets were selected from 21 different platforms for constructing genes regulatory network of mouse NSC. The species, accession numbers, precise descriptions and number of data sets of the 21 platforms are illustrated.

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