Table 1

Parameters of the full pathway model, including references to literature.

Parameter

Value

Reference


[A]tot

5 μM

[73]

[B]tot

0.28 μM

[49]

[R]tot

0.16 μM

[49]

[Y]tot

9.7 μM

[49]

Vcell

1.4 fl

[73]

NA,tot

4215

calculated from above

NB,tot

236

calculated from above

NR,tot

135

calculated from above

NY,tot

8177

calculated from above

NA,tot = NNC

7027

[49,73]

k2

103 s-1

[74]

kA

103 s-1

[75]

ky

100 μM-1 s-1

[76]

kB

15 μM-1 s-1

[76]

k-Y

5 s-1

adjusted to yield steady-state value

k-B

1.35 s-1

(0.35 s-1) [77,78]

γR

0.0061 s-1

[47]

γB

3.14 μM-2 s-1

[47]


The literature values are given in parentheses where different from our parameter values. k-Y was determined by the condition that at steady-state with <a onClick="popup('http://www.biomedcentral.com/1752-0509/5/151/mathml/M123','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/5/151/mathml/M123">View MathML</a>, the concentration [Yp]* = [Y]tot/3[73].

Clausznitzer and Endres BMC Systems Biology 2011 5:151   doi:10.1186/1752-0509-5-151

Open Data