Figure 7.

Integrated response, variance due to transmitted noise and SNR in the full pathway model when varying receptor methylation and demethylation rate constants γ_R and γ_B, respectively. (A) Integrated response of the motor. (B) Illustration of the effects of vanishing γ_R and γ_B on adapted activity (indicated by dot and circle along dose-response curve; left), as well as on time courses (right) for three cases, γ_R → 0 (top right), γ_R/γ_B = const (middle right) and γ_B → 0 (bottom right). For further explanation see text. (C) Variance of the motor including only from receptor switching, ligand diffusion, methylation and phosphorylation. (D) Individual contributions to the variance of the motor. (E) SNR based on the signal response and variance shown in (A) and (C).