Integrated response, variance due to transmitted noise and SNR in the full pathway model when varying receptor methylation and demethylation rate constants γR and γB, respectively. (A) Integrated response of the motor. (B) Illustration of the effects of vanishing γR and γB on adapted activity (indicated by dot and circle along dose-response curve; left), as well as on time courses (right) for three cases, γR → 0 (top right), γR/γB = const (middle right) and γB → 0 (bottom right). For further explanation see text. (C) Variance of the motor including only from receptor switching, ligand diffusion, methylation and phosphorylation. (D) Individual contributions to the variance of the motor. (E) SNR based on the signal response and variance shown in (A) and (C).
Clausznitzer and Endres BMC Systems Biology 2011 5:151 doi:10.1186/1752-0509-5-151