Open Access Highly Accessed Research article

MicroRNAs coordinately regulate protein complexes

Steffen Sass1, Sabine Dietmann12, Ulrike C Burk3, Simone Brabletz3, Dominik Lutter1, Andreas Kowarsch1, Klaus F Mayer1, Thomas Brabletz3, Andreas Ruepp1, Fabian J Theis1* and Yu Wang14*

Author Affiliations

1 MIPS, Institute for Bioinformatics and System Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany

2 Wellcome Trust Center for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK

3 Department of Visceral Surgery, Universitätsklinikum Freiburg, Hugstetter Strasse 55, D-79106, Freiburg, Germany

4 Center for Life and Food Sciences Weihenstephan, Technicial University Munich, Emil-Ramann-Str. 4, D-85354 Freising, Germany

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BMC Systems Biology 2011, 5:136  doi:10.1186/1752-0509-5-136

Published: 25 August 2011

Additional files

Additional file 1:

Supplementary Table S1, complexes that are significantly targeted by single miRNAs (P-value < 0.05, Fisher's exact test)

Format: XLSX Size: 149KB Download file

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Additional file 2:

Supplementary Table S2, complexes that are significantly targeted by clusters of miRNAs (P-value < 0.05, Fisher's exact test)

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Additional file 3:

Supplementary Table S3, over- and underrepresentation of Gene Ontology terms in complex members that are targeted by miRNAs

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Additional file 4:

Supplementary Table S4, over- and underrepresentation of KEGG pathways in complex members that are targeted by miRNAs

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Additional file 5:

Supplementary Table S5, miRNA target sites inferred by PAR-CLIP in experimentally verified protein complexes

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Additional file 6:

Supplementary Table S6, average Pearson correlation of miRNAs that simultaneously target a specific complex

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Additional file 7:

Supplementary Table S7, target interconnectivity of miRNA clusters

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Additional file 8:

Supplementary Figure S1, reduced activity of the CtBP2 and ZEB1 3'UTR-luciferase reporters with increased levels of miR-141 and miR-200c

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