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Degeneration of penicillin production in ethanol-limited chemostat cultivations of Penicillium chrysogenum: A systems biology approach

Rutger D Douma1, Joana M Batista1, Kai M Touw1, Jan AKW Kiel2, Arjen M Krikken2, Zheng Zhao1, Tânia Veiga1, Paul Klaassen3, Roel AL Bovenberg3, Jean-Marc Daran1, Joseph J Heijnen1 and Walter M van Gulik1*

Author Affiliations

1 Department of Biotechnology, Delft University of Technology, Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, 2628 BC Delft, The Netherlands

2 Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, P.O. Box 11103, 9700 CC Groningen, The Netherlands

3 DSM Biotechnology Center, P.O. Box 425, 2600 AK Delft, The Netherlands

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BMC Systems Biology 2011, 5:132  doi:10.1186/1752-0509-5-132

Published: 19 August 2011

Additional files

Additional file 1:

Supplementary material I.pdf. Metabolome data.

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Additional file 2:

Supplementary material II.xls. Transcript data of chemostat cultivations 1 and 2.

Format: XLS Size: 7.6MB Download file

This file can be viewed with: Microsoft Excel Viewer

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