Table 2

Statistical validation of the function assignment

p

Fraction of functions* (raw)

Fraction of functions* (HC)

Fraction of proteins(raw)

Fraction of proteins(HC)


0.20

33.5% (641/1912)

50.4% (502/996)

61.6% (278/451)

73.5% (219/298)


0.40

25.8% (645/2500)

40.0% (532/1330)

64.3% (270/420)

71.4% (227/318)


0.50

26.7% (608/2275)

41.6% (480/1153)

62.4% (232/372)

72.1% (191/265)


0.60

28.2% (583/2068)

44.0% (497/1129)

68.3% (213/312)

74.2% (187/252)


0.80

19.3% (274/1418)

32.7% (231/706)

66.3% (110/166)

75.8% (97/128)


0.90

23.3% (147/630)

37.5% (135/360)

71.3% (57/80)

78.8% (52/66)


0.95

18.2% (78/429)

32.8% (67/204)

59.2% (29/49)

65.8% (25/38)


0.98

23.1% (30/130)

39.2% (29/74)

56.3% (9/16)

75.0% (9/12)


0.99

10.6% (14/132)

18.6% (11/59)

63.6% (7/11)

60.0% (6/10)


Here p is the fraction of training set. *Among all the newly assigned functions to the entire test set proteins, fraction of functions which are also on the original MIPS functional datasets. Fraction of test proteins with at least one function assigned, which has at least one assigned function on the original MIPS functional datasets. Raw outcomes correspond to the original outcomes from our method, and high confidence (HC) outcomes are the selected subset of them whose function assignments are invariant even if the multiple solutions are considered.

Lee et al. BMC Systems Biology 2011 5:126   doi:10.1186/1752-0509-5-126

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