An example of bipartite network representation of protein complexes and component proteins. (a) Complex A is composed of protein a, b, and c, complex B of protein b, d, and e, and complex C of protein b and e. (b) In protein-mode projection, two proteins are linked if they share a complex and the link's weight is assigned as the number of complexes they share. (c) Similarly, in complex-mode projection, two complexes are linked if they share a component protein and the weight is given by the number of proteins they share.
Lee et al. BMC Systems Biology 2011 5:126 doi:10.1186/1752-0509-5-126