Table 2

Biochemical validation of the most significant pathways and biological processes unique for fenofibrate.

GeneGo Pathway Maps

pValue

GO Processes

pValue


Oxidative phosphorylation

7.737e-07

lymphocyte proliferation

2.476e-15

Chemotaxis: CCR4-induced leukocyte adhesion

3.564e-05

mononuclear cell proliferation

5.757e-15

Protein folding: Membrane trafficking and signal transduction of G-alpha (i) heterotrimeric G-protein

2.201e-04

leukocyte adhesion

2.324e-13

Neurophysiological process: Dopamine D2 receptor transactivation of PDGFR in CNS

5.723e-04

cell proliferation

3.118e-13

Immune response: Antigen presentation by MHC class I

6.410e-04

leukocyte migration during inflammatory response

6.116e-12

Transcription: Ligand-Dependent Transcription of Retinoid-Target genes

1.164e-03

endothelial cell migration

1.127e-10

Cell adhesion: Alpha-4 integrins in cell migration and adhesion

1.271e-03

lymphocyte activation

1.994e-10

Chemotaxis: Leukocyte chemotaxis

1.343e-03

leukocyte activation

3.843e-10

Immune response: Role of integrins in NK cells cytotoxicity

1.759e-03

activated T cell proliferation

6.308e-10

Signal transduction: cAMP signaling

1.759e-03

T cell proliferation

9.645e-10


Differentially expressed genes unique for fenofibrate (obtained from the microarray gene expression) were employed to GeneGo Pathway Maps and Gene Ontology (GO) Processes analysis. The 10 most significant pathways maps and biological processes are shown.

Kleemann et al. BMC Systems Biology 2011 5:125   doi:10.1186/1752-0509-5-125

Open Data