Biochemical validation of differential effects of RSV, FF and T09 on inflammation. Quantification of transcription factor activity in liver homogenates and analysis of liver-derived inflammation markers in plasma. ApoE3Leiden mice treated with chow control diet T (for baseline levels) or an atherogenic high cholesterol diet (HC) in the presence or absence of rosuvastatin (RSV); fenofibrate (FF) and LXR agonist T0901317 (T09). A, p65-NFκB; B, C/EBPβ; C, p-STAT3 and circulating markers D, SAA; E, fibrinogen.
Kleemann et al. BMC Systems Biology 2011 5:125 doi:10.1186/1752-0509-5-125