Effect of rosuvastatin on inflammatory networks and pathways. Major hepatic inflammatory pathways activated by high cholesterol (HC) feeding (identified in ) were plotted in one graph and the effects of cardiovascular drugs were analyzed. White arrows indicate the pathways that were active in presence of a drug. Cytokines and chemokines are shown in green, transcription factors in red, adaptor molecules in blue, factors with catalytic or enzymatic activity in yellow. Filled red circles (blue circles) indicate that expression of a factor is upregulated (downregulated). Red (blue) boxes indicate upregulated (downregulated) gene clusters. A, Pathways and transcription factors affected by rosuvastatin (RSV). B, Genes from the network regulated differentially by RSV, FF and T09 with thermometers 1,2 and 3 indicating RSV, FF, T09, respectively. Red (blue) color of a thermometer indicates upregulation (downregulation). C, Genes upregulated only by RSV and T09.
Kleemann et al. BMC Systems Biology 2011 5:125 doi:10.1186/1752-0509-5-125