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Open Access Highly Accessed Methodology article

A retrosynthetic biology approach to metabolic pathway design for therapeutic production

Pablo Carbonell, Anne-Gaëlle Planson, Davide Fichera and Jean-Loup Faulon*

Author Affiliations

iSSB, Institute of Systems and Synthetic Biology, University of Evry, Genopole Campus 1, Genavenir 6, 5 rue Henri Desbruères, 91030 EVRY Cedex, France

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BMC Systems Biology 2011, 5:122  doi:10.1186/1752-0509-5-122

Published: 5 August 2011

Additional files

Additional file 1:

Pathway ranking accuracies for different values of parameters (λtox, λflux). Figure S1 plots pathway ranking accuracy for different values of parameter λtox without considering fluxes (λflux = 0); optimal value is obtained for . Figure S2 plots pathway ranking accuracy for different values of parameter λflux without considering toxicity (λtox = 0); optimal value is obtained for . Figure S3 plots pathway ranking accuracy for different values of parameters (λtox, λflux); optimal values are (, ).

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