Table 4

Growth phenotypes predicted by the model under a variety of routinely utilized laboratory conditions*

Light

Dark


Electron Acceptor


O2a

DMSOa

None


Succinate + NH3

+/+b

+/-

+/-

-/-

Succinate + Glutamate

+/+ b

+/-

+/-

-/-

Lactate + NH3

+/+ b

+/-

+/-

-/-

Glutamate only

+/-

+/-

+/-

-/-

CO2 + H2 + NH3

+/-

-/-

-/-

-/-

CO2 + H2 + N2

+/-

-/-

-/-

-/-


* +/+ Growth and H2 production predicted; +/- Growth but no H2 production predicted; -/- No growth

a Oxygen (O2) or DMSO was used as the sole electron acceptors in simulations.

b Succinate and lactate uptake rates were set to 3 mmol/g DW h, while the NH3 and glutamate uptake rates were set to 1 mmol/g DW h, as these are within the rate of experimentally observed uptake rates for these substrates. CO2, H2 and N2 uptake rates were set to 1 mmol/g DW h for photoautotrophic growth simulations.

Imam et al. BMC Systems Biology 2011 5:116   doi:10.1186/1752-0509-5-116

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