Table 1

Parameters of the model

Intial Conditions

Symbol

Values


Resting Teff cell population size

Er

En0 = 0 cells

Resting Treg cell population size

Rr

Rn0 = 0 cells

Activated Teff cell population size

E

Ea0 = 1000 cells

Activated Treg cell population size

R

Ra0 = 200 cells

Reversible Damage

l

l0 = 0

Irreversible Damage

L

L0 = 0


Parameter description

Symbol

Values


Antigen Presentation

δ

1 day-1 (35)

Anergy

β

0.01 day-1

Memory

η

0.01 day-1

Maximum Teff proliferation rate

αE

[1:2] day-1 (36)

Maximum Treg proliferation and activation rate

αR

[0.25:2] day-1

Teff death, anergy and migration Rate

γE

0.2 day-1 (37)

Treg death, anergy and migration Rate

γR

0.2 day-1

Teff cell population sizes leading to half maximal effect counterpart

Ke

1000 cells

Treg cell population sizes leading to half maximal effect

Kr

200 cells

Hill coefficient

h

5

Reversible damage rate

d1

1 day-1

Irreversible damage rate

d2

0.02 day-1

Threshold

a

22800 cells

Recovery

r

0.1 day-1


Vélez de Mendizábal et al. BMC Systems Biology 2011 5:114   doi:10.1186/1752-0509-5-114

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